Detalhe da pesquisa
1.
Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
Proc Natl Acad Sci U S A
; 120(41): e2300258120, 2023 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37801475
2.
Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease.
Alzheimers Dement
; 19(6): 2239-2252, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36448627
3.
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
J Biol Chem
; 295(31): 10662-10676, 2020 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32493775
4.
Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure.
Circ Res
; 122(10): e75-e83, 2018 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29483093
5.
Common fibrillar spines of amyloid-ß and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.
J Biol Chem
; 293(8): 2888-2902, 2018 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29282295
6.
Atomic-resolution structure of a disease-relevant Aß(1-42) amyloid fibril.
Proc Natl Acad Sci U S A
; 113(34): E4976-84, 2016 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27469165
7.
Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-ß Peptide.
J Biol Chem
; 292(8): 3172-3185, 2017 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28049728
8.
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-ß.
Nature
; 485(7400): 651-5, 2012 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22660329
9.
Structural differences between amyloid beta oligomers.
Biochem Biophys Res Commun
; 477(4): 700-705, 2016 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27363332
10.
Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes.
Proc Natl Acad Sci U S A
; 110(8): 3077-82, 2013 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23365139
11.
Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells.
J Mol Cell Cardiol
; 79: 295-302, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25463275
12.
Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aß pathology and modulates Aß oligomerization.
Neurobiol Dis
; 82: 552-560, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26369878
13.
Out-of-register ß-sheets suggest a pathway to toxic amyloid aggregates.
Proc Natl Acad Sci U S A
; 109(51): 20913-8, 2012 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23213214
14.
A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aß, and frank neuronal loss.
J Neurosci
; 33(15): 6245-56, 2013 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23575824
15.
Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques.
Neurobiol Dis
; 71: 53-61, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25092575
16.
Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aß deposition and tau pathology in 3xTg-AD mice.
J Neurochem
; 126(4): 473-82, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23672786
17.
CD45 deficiency drives amyloid-ß peptide oligomers and neuronal loss in Alzheimer's disease mice.
J Neurosci
; 31(4): 1355-65, 2011 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21273420
18.
Amyloid-ß annular protofibrils evade fibrillar fate in Alzheimer disease brain.
J Biol Chem
; 286(25): 22122-30, 2011 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21507938
19.
Heterodivalent linked macrocyclic ß-sheets with enhanced activity against Aß aggregation: two sites are better than one.
J Am Chem Soc
; 134(34): 14179-84, 2012 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22827298
20.
A specific amyloid-beta protein assembly in the brain impairs memory.
Nature
; 440(7082): 352-7, 2006 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-16541076